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Cosmic Fantasy is a series of 5 storybook/RPGs created for the PC-Engine by Shin Nihon Laser Soft. They follow the crew of a space ship as the explore the galaxy.
Cosmic Fantasy 2 has, at least, a harpy as a regularly appearing enemy.
Cosmic Fantasy 4: Chapter 1 has, at least, a very fishy looking mermaid as a regularly appearing enemy.