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DOTA, or Defense of the Ancients as no one calls it, was originally a custom map for Warcraft 3. Kill mobs, buy gear, break towers. And don't get your upgrade order wrong, or your entire team will rage quit on you.
Medusa is one of the hero characters in DOTA 2.
The Naga Siren is one of the heroes in DOTA and DOTA 2. In DOTA she used the model of the... Naga Siren. She has mostly long-range attacks.